When given by IV, coleus can cause flushing and low blood pressure. Herbalist Cahn, D., Melman, A., Valcic, M., and Christ, G. J. Forskolin: a promising new adjunct to intracavernous pharmacotherapy. View abstract. Forskolin: From a ayurvedic remedy to a modern agent. (adsbygoogle = window.adsbygoogle || []).push({}); February 5, 2015 View abstract. Bleeding disorders: There is some evidence that forskolin, a chemical found in coleus, might increase the risk of bleeding in some people. Since only eight enzymes are involved in the biosynthetic pathway, all of which are known now, this system is very suitable to study the regulation of this pathway. Medicinal Coleus (Coleus forskohlii . Coleus might slow blood clotting. View abstract. Ammon HP, Muller AB. J Ethnopharmacol 1981;3(1):1-13. Contact Dermatitis 1991;25(2):128-129. The plant-derived forskolin is used as basic molecule for semisynthetic derivatives. Contact Dermatitis 1987;17(2):109-110. Coleus carnosus Hassk. Heart disease: Forskolin, a chemical found in coleus, might lower blood pressure. View abstract. Nebbioso M, Belcaro G, Librando A, et al. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. 1998;93 Suppl 1:66-75. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. View abstract. Invest Ophthalmol Vis Sci 1984;25:268-77. View abstract. Coleus increases blood flow. Forskolin is a chemical found in the roots of the coleus plant. Acta Endocrinol (Copenh) 1985;108(3):367-371. Varieties Maimul, Manganiperu, Garmai are some of the popular varieties. Coleus forskohlii is an important indigenous medicinal plant in India. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Medicinal and Aromatic Plants. View abstract. It produces a more powerful heartbeat and widening of the blood vessels, which lowers blood pressure. Coleus amboinicus Lour. Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. 2012;28(5):536-41. View abstract. Caprioli J, Sears M, Bausher L, et al. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. Black Dragon. Also more or less differentiated axenic cultures, namely transformed and untransformed root cultures, shoot cultures, and shoot-forming callus cultures, were reported to produce forskolin. Life Sci 1997;61(25):2435-2442. View abstract. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. Li, Z. and Wang, J. Forskolin is a chemical found in the roots of the coleus plant. J Ocul Pharmacol Ther. Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. This species is named after Swedish Naturalist Peter Forskal who is credited with its discovery. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Christenson JT, Thulesius O, Nazzal MM. Shen, Y. H. and Xu, Y. L. Two new diterpenoids from Coleus forskohlii. J Asian Nat Prod Res 2005;7(6):811-815. Coleus species are native to tropical and subtropical regions of Africa, Australia, the East Indies, the Malay Archipelago, and the Philippines. Bartels, S. P., Lee, S. R., and Neufeld, A. H. The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits. View abstract. 2012;54(1 Suppl 4):77-82. Battochio, A. P., Sartori, M. S., and Coelho, C. A. Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats. Insufficient Evidence to Rate Effectiveness for... Vitamin D Deficiency: How Much Vitamin D Is Enough? Coleus forskohlii preparations used as eye drops are known to reduce eye pressure in glaucoma. These flowers are mostly blue or lilac-blue and grow in terminal spikelike racemes or panicles. Coleus blumei is not used for medicinal purposes but there is a high demand for this plant as an ornamental. Xu, L. L., Lu, J., Li, W. J., and Kong, L. Y. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. This cultivar grows to a height of 12 inches and is relatively smaller in size compared to the rest of the Coleus plants. View abstract. Agarwal KC, Zielinski BA, Maitra RS. During screening programs for useful medicinal plants in India, two different groups independently discovered roots of C. forskohlii as a source for a potential drug. Coleus use as medicine has ancient origins used in Ayurveda (Indian traditional medicine) with verifiable texts mentioned from ancient Sanskrit writings where it is used as a health tonic, treatment for heart problems, chest pains, lung ailments, digestive disorder and sleeplessness (insomnia). Asia Pac J Clin Nutr 2006;15(2):267-274. Thromb Haemost 1989;61:106-10. View abstract. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Short communication. Later, Brown (1810) reclassified this species as Plectranthus scutellarioides, and this name was also used by Blume (1826) for another specimen which was similar to the one of Linnaeus. Arch Int Pharmacodyn.Ther. An example for this is the production of forskolin by cell cultures of C. forskohlii. Forskolin, which was detected only quite recently as a promising drug because of its activity towards adenylate cyclase, is used as a research tool for studying the function of this enzyme. View abstract. Abstract . Zhongguo Zhong.Yao Za Zhi. Some species, especially those with showy colorful foliage, are grown as ornamentals all over the world. Some calcium channel blockers include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others. C. amboinicus) are used as spices. The tuberous roots contain a labdane diterpene which was called coleonol by one group and forskolin by the other. In 1974 research carried out by Hoechst Pharmaceuticals and the Indian Central Drug Research Institute in a search for sources of new drugs in the medicinal plant world, found that extracts of Coleus root reduced muscle spasms and lowered blood pressure. The roots are fasciculate, thick, succulent and contain the unique chemical forskolin. View abstract. J Cardiovasc.Pharmacol 1992;19(5):779-789. Ethnobotanical Uses: Food (Herb and Spice : The leaves are used to add flavor to meat and bean dishes, especially in Caribbean cuisine. View abstract. With easy manipulations of the culture medium, the biosynthesis of RA can be stimulated. Ayu. View abstract. The effects of the plant have not been scientifically explored in great detail, but the plant is known to have been used by the Mazatec Indians of southern Mexico for its mind-altering effects. Template:Cite book Coleus forskohlii has traditionally been used t o treat hypertension, congest ive heart failure, and angina. Cell cultures of C. blumei accumulate up to 21% of the cell dry weight as rosmarinic acid, which is one of the highest accumulation levels of secondary products in plant cell cultures ever found, compared to 2-3% in the plant. Wien Med Wochenschr 12-31-1986;136(23-24):637-641. Jpn.J Ophthalmol. J Neural Transm. S Afr Med J 1987;71:570-1. J Int Med Res. Acta Cir.Bras. Meyer BH, Stulting AA, Muller FO, et al. View abstract. At this time there is not enough scientific information to determine an appropriate range of doses for coleus. Planta Med 1996;62(2):169-172. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. (Feverfew), From Herb to Medicine: Forms of Herbal Products. Are there any interactions with medications. View abstract. Nutrients. Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M. The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye. Water stagnation should be avoided. J Urol 1996;155(5):1789-1794. [Protective effect of forskolin in acetylcholine provocation in healthy probands. Forskolin: a potential antimetastatic agent. Other preparations from Coleus are traditionally used against heart diseases, abdominal colic, respiratory disorders, painful micturition, insomnia, and convulsions. View abstract. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. 2005;20(3):229-236. It is used as a medicinal plant in India, Indonesia, and Mexico. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial. Eur.J Vasc.Surg 1991;5(3):271-275. Bersudsky, Y., Kotler, M., Shifrin, M., and Belmaker, R. H. A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Topical forskolin on left ventricular function coleus plant medicinal uses dilated cardiomyopathy 61 ( 25 ):2435-2442 Lichti, K. 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